What is one disadvantage of using ionic contrast media?

The choice of higher osmolarity as a disadvantage of using ionic contrast media is correct. Ionic contrast media typically have a higher osmolarity compared to non-ionic contrast agents. This elevated osmolarity can lead to several physiological effects, including discomfort, pain at the injection site, and potential for adverse reactions such as vasodilation or even contrast-induced nephropathy. High osmolarity can also increase the risk of complications in sensitive patients, such as those with pre-existing kidney issues or dehydration.

In contrast, non-ionic contrast media, which have a lower osmolarity, tend to be better tolerated and associated with a lower incidence of adverse reactions. Therefore, the higher osmolarity of ionic contrast agents is a significant disadvantage in their use in medical imaging, as it can impact patient safety and comfort.